Regional cooperation in Central Asia and the Caucasus following the Cold War, due to geographical proximity, historical-cultural commonalities, and shared security concerns, has become one of the important axes of countries' foreign policy; however, the current situation indicates weak intra-regional integration and geopolitical complexities that limit the formation of stable arrangements. In this framework, following the collapse of the Soviet Union, Iran faced the issue of "cognitive confusion" and a lack of disciplined academic knowledge regarding the region, and consequently failed to establish an effective language of dialogue and strategic prioritization for engagement with these countries. On the other hand, Russia's paternalistic role, China's expanding influence through the "Belt and Road" initiative, the presence of the U.S. and Israel, and internal regional challenges such as political authoritarianism, ethnic-religious divides, environmental crises, and extremism have made regional interactions more complex. Proposed strategies emphasize low-cost Iranian investment in existing regional organizations, the formulation of short-term and long-term strategic documents, adopting a realistic and non-U.S.-centric approach in the new Eurasia, clarifying objectives and avoiding tension-provoking policies, strengthening multilateral diplomacy and mediation, utilizing economic capacities and connectivity to transit routes (including Chabahar), and developing paradiplomacy and the systematic linkage of the Ministry of Foreign Affairs with academic elites to enhance national influence and interests.